بررسی رابطه سقط جنین خود به خودی و وجود آنتی‌بادی‌های ضد تیروئید در خون مادر

Background and Aim: Spontaneous abortion is the most common pregnancy complication with no reasonable causes in most cases. Some research imply the role of antithyroid antibodies ( e.g.AntiTPO-Ab and AntiTG-Ab) that can cause spontaneous abortion. In the present study, the association between abortion and presence of antthyroid antibodies in mother’s serum was assessed. Materials and Methods: In this case control study, 102 women aged 15-45 years, who referred to Hajar hospital of Shahrekord or the clinic affiliated to Shahrekord University of Medical Sciences were selected. Out of 102 women, 51 who had had abortion selected as the cases and 51 pregnant women with gestational age less than 20 weeks were include as the controls. .In order to assess antithyroid antibodies level, blood samples were taken from every participant with normal TSH level.. Anti-thyroid peroxidase antibody (Anti-TPO-Ab)>50 IU/ml and anti-thyroglobulin antibody (Anti-TG-Abs)>75 IU/ml were defined as Positive. The obtained results were analyzed by means of t-test and χ2 ,using statistical SPSS software. Results: Out of 51 subjects, 18 had positive Anti-TPO-Ab, of which -10 were among the cases and 8 belonged to the controls. Out of 18 women with positive AntiTG-Ab, 11 cases were in the control group and 7 were in the cases. The differences between the control group and the amounts of Anti-TPO-Abs (P=0.468) and Anti-TG-Abs (P=0.675) were not swignificant. Conclusion: The results revealed that there is no association between abortion and presence of antithyroid antibodies in mother’s serum. Other abortion causes such as various kinds of infections and smoking might be involved which requires more research.